Neurotransmitters: NMDA receptors: do glia hold the key?

نویسنده

  • Stuart Cull-Candy
چکیده

NMDA receptor stimulation requires binding of a 'co-agonist' and the neurotransmitter glutamate at separate sites. Are ligands for the co-agonist site liberated by glia, following activation of glial glutamate receptors?

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Atypical neural messengers.

Notions of what constitutes a neurotransmitter have changed markedly with the advent in the past decade of synaptic molecules, which satisfy key neurotransmitter criteria but differ radically from classical transmitters. Thus, NO and carbon monoxide are neither stored in synaptic vesicles nor released by exocytosis. These gases do not act via traditional receptors on postsynaptic membranes. In ...

متن کامل

NMDA receptor mediates proliferation and CREB phosphorylation in postnatal Müller glia-derived retinal progenitors

PURPOSE Postnatal retinal Müller glia are considered to be retinal progenitors as they retain the ability to dedifferentiate, proliferate, and differentiate to new retinal glia and neurons after injury. The proliferation and differentiation processes are coordinated by several extrinsic factors and neurotransmitters, including glutamate. Thus, the appropriate numbers and proportions of the diff...

متن کامل

Novel neurotransmitters and their neuropsychiatric relevance.

OBJECTIVE The purpose of this review is to integrate insights regarding novel neurotransmitters or neuromodulators of neuropsychiatric significance. METHOD Evolving concepts of neurotransmitter criteria are reviewed in light of the unexpected properties displayed by recently identified transmitters. RESULTS Classic criteria for transmitters were based on the properties of acetylcholine but ...

متن کامل

D-serine regulation of NMDA receptor activity.

The N-Methyl-D-aspartate-type glutamate receptor (NMDAR) plays a key role in several important processes involving the nervous system, including brain development, synaptic plasticity, and learning. Unlike other neurotransmitter receptors, which are activated by individual neurotransmitters, activation of NMDARs requires the binding of a coagonist (D-serine or glycine) in addition to glutamate....

متن کامل

Age-dependent remodelling of ionotropic signalling in cortical astroglia.

Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial. Stimulation of neuronal afferents in mice neocortex triggers complex glial synaptic currents (GSCs) mediated by NMDA, P2X and AMPA receptors and glutamate transporters. In addition, astrocytes demonstrate spontaneous 'miniature' GSCs resulting fro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Current Biology

دوره 5  شماره 

صفحات  -

تاریخ انتشار 1995